Supplementary Files
Keywords
maternal complications
insulin resistance
How to Cite
Abstract
Objective: The objective of this study was to investigate the association between polycystic ovaries (PCOs) and maternal complications during pregnancy.
Methods: This prospective case-control study was conducted at Shahida Islam Medical Complex from November 2024 to June 2025. Data was collected from inpatient pregnant females. Demographic information was recorded, and patients were divided into cases and controls based on the status of PCOs, as diagnosed clinically according to the Rotterdam criteria. Before delivery, 5ml of venous blood was collected for estimation of lab parameters. Patients were followed till delivery, and maternal-fetal outcomes were recorded.
Results: A significant association between PCOS and gestational diabetes was found (ꭕ=11.35, p< 0.0001). Logistic regression analysis, using a backwards stepwise method, identified LH, FSH, Testosterone, Insulin Resistance, and Systolic BP as significant predictors of Gestational Diabetes. Notably, higher levels of LH and FSH were associated with increased risk (p < 0.0001 and p = 0.0000, respectively). The correlation matrix confirmed strong correlations between Testosterone and LH (r = 0.83), and between Insulin Resistance and Glucose levels (r = 0.83), highlighting metabolic dysfunctions in PCOS. Conclusion: These findings underscore the critical role of hormonal imbalances and insulin resistance in increasing the risk of pregnancy complications in PCOS patients, emphasising the need for early screening and intervention.
Keywords: Polycystic Ovary Syndrome, Pregnancy Complications, Gestational Diabetes Mellitus, Insulin Resistance, Pregnancy Outcome, Hypertension, Pregnancy-Induced, Maternal Health, Neonatal Outcome.
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